Iriomoteolide-1a, a potent cytotoxic 20-membered macrolide from a benthic dinoflagellate amphidinium species.

نویسندگان

  • Masashi Tsuda
  • Keiko Oguchi
  • Rie Iwamoto
  • Yumiko Okamoto
  • Jun'ichi Kobayashi
  • Eri Fukushi
  • Jun Kawabata
  • Tomoko Ozawa
  • Atsunori Masuda
  • Yoshiaki Kitaya
  • Kenji Omasa
چکیده

A potent cytotoxic 20-membered macrolide, iriomoteolide-1a (1), has been isolated from a benthic dinoflagellate Amphidinium sp. (strain HYA024), and the structure was elucidated on the basis of detailed analyses of 2-D NMR data. The relative and absolute stereochemistries were assigned by the combination of conformational analyses using NMR data and modified Mosher's method of 1.

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عنوان ژورنال:
  • The Journal of organic chemistry

دوره 72 12  شماره 

صفحات  -

تاریخ انتشار 2007